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Cytoxan

125.48 895.96 

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Description

Common use

Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.

Dosage and direction

For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.

Precautions

Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.

Contraindications

Hypersensitivity, severe myelosuppression.

Side effects

Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.

Drug interaction

Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Overdose

Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.

Storage

Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Апу specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Additional information

Dose

50mg

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120pills, 180pills, 30pills, 360pills, 60pills, 90pills

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Description
ContentCommon use

Cytoxan belongs to the drugs for treatment of cancer with cytotoxic effect. Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. They are the active compounds, and they slow the growth of cancer cells inhibiting their proliferation and metabolism. First of all this effect concerns cells of uncontrolled growing but also damages other cells of the body resulting in serious side effects. Cytoxan also can be referred to as immunosuppressive agent. Cytoxan is used to treat malignant lymphoma (lymphocytic and gistiotsitarnaya lymphoma, lymphogranulomatosis, Burkitt lymphoma, lymphoma, mixed type), multiple myeloma, leukemias (lymphocytic leukemia, granulocytic leukemia, myelocytic leukemia, acute lymphoblastic leukemia in children), neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma.



Dosage and direction

For adults and children Cytoxan is administered intravenously by 40-50 mg/kg over 3-5 days in divided doses. An oral dose of this medication is oral dose is 1-5 mg/kg daily. Dosage should be corrected on a basis of regular blood tests for white blood cell count. This medication can be taken orally also with or without food.



Precautions

Carefulness should be exercised in patients with myelosuppression, liver or kidney disorders, with the previous radiation and chemotherapy. During treatment a regular monitoring of blood and urine count tests (for the presence of red blood cells) is required. In women of childbearing age a reliable contraception is recommended if Cytoxan is taken.



Contraindications

Hypersensitivity, severe myelosuppression.



Side effects

Side effects of Cytoxan include vulnerability to infections, the development of a secondary cancer, typically of the bladder, lymph nodes, or bone marrow. A secondary cancer may occur several years after the drug is given.



Drug interaction

Notify your doctor before to take anticancer drugs such as doxorubicin, allopurinol, and phenobarbital with Cytoxan. Correction of steroid hormones dosage should be done if they are taken with Cytoxan in patients with removed adrenal glands.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.



Overdose

Symptoms of Cytoxan overdose are not expected. If you suppose that took too much of it call your doctor immediately.



Storage

Store at room temperature between 20-25 C (68-77 F). Keep out of heat, moisture, sunlight, of the reach of children. Storage in a bathroom is not recommended.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Апу specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use

Hydrea is used to treat certain types of cancer (melanoma, chronic myelocytic leukemia, cancer of the ovary, and primary skin cancer of the head and neck) or sickled red blood cells. Active ingredient of this drug is hydroxyurea. The exact mechanism of its action is unknown, it is supposed that it is cell cycle specific for the S phase of cell division, it interfere with synthesis of DNA, with no effect on synthesis of RNA or protein.



Dosage and direction

Take this potent medication exactly as prescribed. Drink plenty of water during treatment to assist your kidney to remove the drug from the blood and diminish side effects. The medicine may be taken with or without food. You may be advised by your doctor to poor the content of Hydrea capsule into a glass of water, if so mix it throughly and drink whole immediately. Do not touch or inhale the drug powder from the capsule. Even if such symptoms as nausea or vomiting appear, do not stop taking this medication. Contact your doctor if you are immediately vomiting after the dose. This drug may increase the risk of sickness and inflammation due to its effect on amount of blood cells which control immunity.



Precautions

Before to take Hydrea consult your doctor if you are being treated with radiation therapy or are currently on interferon (Actimmune, Betaseron, Roferon, Intron, Infergen, Alferon, Rebetron, Rebif). Notify your doctor about diseases you have and especially about poor bone marrow function, liver disease, or kidney disease.



Contraindications

Do not take Hydrea if you are allergic to the components of the drug. This medicine is contraindicated in the patients with bone marrow depression (leukopenia or thrombocytopenia). This medicine may be harmful to an unborn baby. Do not take Hydrea if you are pregnant or breastfeeding.



Possible side effect

Besides signs of allergic reaction such as facial swelling, skin rash and eruptions, hives, and pinpoint red spots on your skin Hydrea may cause skin ulcers, red patches, or darkened skin, symptoms of fever, flu, chills, white patches or sores inside your mouth or on your lips, body aches, nausea or vomiting, loss of appetite, diarrhea, easy bruising or bleeding, unusual weakness.



Drug interaction

Do not start or stop treatment with any medication without your doctor's permission. Inform your health care advisor about all drugs, health products, vitamins, minerals, and supplement substances you are currently taking and especially about anti-cancer drugs, didanosine, stavudine, to treat gout.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Immediate medical help is needed if excessive amount of this drug was taken. Contact your doctor the soonest if somebody swallowed too much of Hydrea by chance or you suspect overdose. Symptoms of overdose are worsened side effects such as violet erythema, soreness, severe generalized hyperpigmentation of the skin, edema on palms and soles followed by scaling of hands and feet, and stomatitis.



Storage

Store Hydrea at room temperature between 20 and 25 C (68 and 77 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Common use

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.



Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.



Precautions

Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.



Contraindications

This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.



Possible side effect

Methotrexate is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).



Missed dose

Consult your doctor if you miss a dose of this medicine.



Overdose

Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.



Storage

Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Common use Nolvadex is a non-steroid anti-estrogen which competitively inhibits estrogen receptors in the target organs and tumors in them. Mechanism of its action is not completely investigated though it is known that a complex of Nolvadex with the receptor and cofactor appears and than it is transferred to the cell nucleus preventing hypertrophy of the cells which depend on regulation by estrogen. The effect of the medication can last several weeks after a single dose. Nolvadex is able to cause ovulation in women, stimulation production of gonadotropic hormones of hypophysis. In men with oligospermia it increases concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. Nolvadex is used to treat breast cancer in women and in men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanomas and sarcomas of the soft tissues with estrogen receptors, cancer of the ovary. Dosage and direction Take it exactly as recommended by your physician as the dosage depends on your condition. Long treatment (about 2 years) is advised. Take this medication with food and a big glass of water as a single dose or divide it in two (taken in the morning and the evening), do not chew or crush them. Precautions This medication may increase the possibility of developing endometrial cancer. Patients who are treated with Nolvadex should be monitored for any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure. Contraindications Nolvadex is contradicted in patients with hypersensitivity to this medication and also in women who are threated by coumarin-type anticoagulant therapy or in women with deep vein thrombosis or pulmonary embolus in history, pregnant or breastfeeding women. Cautiousness should be exercised in patients with eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, severe thrombophlebitis, thromboembolism (also in history). Side effects Side effects are not expected. If they change from minor to severe you should immediately inform your doctor about it. Side effects caused by Nolvadex are: hot flashes, nausea, vomiting, weight gain, abnormal menstrual periods. Drug interaction Nolvadex is able to cause abnormalities in liver and blood tests, so regular monitoring of side effects caused by Nolvadex is required. If such signs as jaundice and bleeding appear a patient should immediately seek for immediate medical help. Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time. Overdose Acute overdosage in humans has not been reported. In patients with metastatic cancer treated with the maximally tolerated doses of Nolvadex side acute neurotoxicity manifested by tremor, hyperreflexia, unsteady gait and dizziness were observed. If you supposes that took too much of this medication look for immediate medical help and contact your doctor. Storage Store at room temperature between 20-25 C (68-77 F). Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.Common use

Zofran is a prescription medicine that has been licensed to prevent nausea and vomiting due to several causes



Doses and directions

The dose of Zofran depends on the type of chemotherapy -high risk for nausea and vomiting or medium risk.

High-risk chemotherapy: The dose of Zofran for high-risk chemotherapy is Zofran 24 mg (taken as three 8 mg tablets) 30 minutes before chemotherapy.

Medium-risk chemotherapy: The dose of Zofran for medium-risk chemotherapy is Zofran 8 mg twice daily. The first dose should be taken 30 minutes before chemotherapy, and the second dose should be taken eight hours after the first dose. After that, Zofran should be taken twice a day (about every 12 hours) until one to two days after chemotherapy.



Precations

You should talk with your healthcare provider prior to taking Zofran if you have:

Liver problems, including cirrhosis,an arrhythmia (an irregular heart rhythm), especially long QT syndrome,phenylketonuria,any allergies, including allergies to foods, dyes, or preservatives.

Also, let your healthcare provider know if you:are pregnant or thinking of becoming pregnant,breastfeeding,have severe or constant nausea or vomiting that is not helped by Zofran. Also talk with your healthcare provider if you are vomiting blood,Have severe vomiting and diarrhea. This combination of problems can lead to dehydration and electrolyte imbalances.



Side effects

If you develop any sexual side effects while taking Zofran, be sure to talk with your healthcare provider

Drug interactions

The following sections explain in detail the potentially negative interactions that can occur when Zofran is combined with any of the drugs listed above.

Apomorphine,Carbamazepine,Phenytoin,Rifampicin,drugs Containing Tramadol.



Missed dose

If you miss a dose of Zofran and are taking it regularly, you should take it as soon as you can remember it. If you miss for long time and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at a time to compensate fro the missed dose.



Storage

Zofran should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store it away from heat, moisture, and direct light, in a tight, light-resistant container. Do not store in the bathroom. Keep Zofran out of the reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Common use

Xeloda is used to treat cancer. It is pro-medication, it turns into a cytotoxic compound 5-fluorouracil (5-FU). 5-FU is formed in the tumors with help of thymidine phosphorylase, thus systemic influence of 5-FU on healthy tissues is minimal. The medication is used to treat breast cancer or colon or rectum cancer (also one with metastases) including types of the cancer resistant to paclitaxel and anthracyclines.



Dosage and direction

Take the medication exactly as it was administered to you. Treatment usually consists in a treatment cycle of 2 weeks on and 1 week off. This cycle is repeated up to 8 times. Take it orally with a full glass of water, 30 minutes after a meal. The daily dose is 2.5 g/sq.m/day (the daily dose should be divided in two intakes).



Precautions

While you are on Xeloda use effective birth control. Notify your doctor about your liver or kidney disease, a history of coronary artery disease, or if you are treated by folic acid, a blood thinner (Coumadin, warfarin), phenytoin (Dilantin), leucovorin (Wellcovorin). Your doctor may want you to have regular blood tests while you are treated by Xeloda. Do not miss any appointments. E attentive while driving or operating machinery as this drug may make you dizzy or fainting.



Contraindications

Do not start treatment with Xeloda if you have allergy to capecitabine or fluorouracil (Adrucil), kidney disease or dihydropyrimidine dehydrogenase deficiency, pregnant and breastfeeding women, adolescents under 18 years of age.



Possible side effect

Notify your doctor immediately if you have severe adverse reactions such as severe vomiting or diarrhea, abdominal pain, stomatitis, constipation, epigastric pain, dyspepsia, dry mouth, flatulence, loss of appetite, oral candidiasis, hyperbilirubinemia, pain or redness of your hands or feet, fever or flu symptoms, jaundice, angina, sudden numbness or weakness, fainting, itching, loss of fluid in the body, edema of extremities, difficulty breathing. Patients over 80 years of age are more likely to experience side effects from Xeloda.



Drug interaction

Appointment of anticoagulants of cumarine type should be done not earlier than 1 month after treatment with Xeloda due to possible hypocoagulation and bleeding. Xeloda increases effects of indirect anticoagulants, increases blood levels of phenytoin. Antacids which contain aluminum and magnesium hydroxide increase blood concentrations of capecitabine and metabolite 5'-Deoxy-5-fluorocytidine. Cyclophosphamide increases toxicity due to increase of thymidine activity. Calcium folinate increases toxicity of capecitabine due to increased toxicity of fluorouracil.



Missed dose

Take the dose you missed as soon as you remember. If it is almost time of your next intake just skip it and return to your regular schedule.



Overdose

Overdose symptoms include nausea, vomiting, diarrhea, fever, bloody stools, coughing up blood.



Storage

Store in a dry place away from sunlight at room temperature between 15-30 C (59-86 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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Additional information
Dose

50mg

Pack

120pills, 180pills, 30pills, 360pills, 60pills, 90pills

Dose

500mg

Pack

120pills, 240pills, 30pills, 60pills, 90pills

Dose

2, 5mg

Pack

120pills, 30pills, 60pills, 90pills

Dose

10mg, 20mg

Pack

120pills, 180pills, 20pills, 270pills, 30pills, 360pills, 60pills, 90pills

Dose

4mg, 8mg

Pack

120pills, 180pills, 30pills, 40pills, 60pills, 90pills

Dose

500mg

Pack

10pills, 20pills